CV

• BS Trinity College 60
• MD Rochester 65
• Pathology resident, Strong Memorial Hospital 65-66, 69-70
• Fellow in Neuropathology 70-72
• Asst. and Assoc. Professor of  Pathology. Univ. Colorado 72-82
• Professor of  Pathology at UM since 82

Research interests and techniques

Normal function and properties of glia; neurotransmitter transport in glia; role of glia and steroids in neuroprotection; mechanisms and significance of reactive gliosis; role of glia in various neurological conditions (trauma, aging/Alzheimer's disease, Parkinson's disease, brain edema, liver failure); the role of oxidative stress and the mitochondrial permeability transition in CNS trauma and liver failure. Additionally, we are investigating the cellular and molecular events associated with human spinal cord injury. Our studies utilize animal models of human disease and the use of cell culture (astrocytes, microglia, neurons, endothelial cells). Techniques employed in our laboratory include morphology (including immunohistochemistry, confocal microscopy, in situ hybridization, electron microscopy), molecular biology, analysis of membrane receptors, calcium imaging and various biochemical / pharmacological methods.

Papers

Panickar KS, Jayakumar AR, Norenberg MD: Differential response of neural cells to trauma-induced free radical production. Neurochem Res. 27:161-166, 2002..

Bai G, Rama Rao KV, Murthy ChRK, Panickar KS, Jayakumar AR, Norenberg MD: Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes. J Neurosci Res 66: 981-991, 2001.

Murthy ChRK, Rama Rao KV, Bai G, Norenberg MD: Ammonia induced production of free radicals in primary cultures of rat astrocytes. J Neurosci Res 66: 282-288, 2001.

Bruce JH, Norenberg MD, Kraydieh S, Puckett W, Marcillo A, Dietrich D: Schwannosis: role of gliosis and proteoglycan in human spinal cord injury. J Neurotrauma 17: 781-788, 2000.

Zhou B, Norenberg MD: Ammonia downregulates GLAST mRNA glutamate transporter in cultured astrocytes. Neurosci Lett 276:145-148, 1999.